Confusion (Oxybutynin)

Who you are:
An FY2 in General practice.

Who the patient is:
75-year-old Steve Austin came to the hospital with some concerns.

Additional Information:
He came to the clinic 2 weeks ago and was started on oxybutynin for stress incontinence. He used it for a week but that did not help, and the dose was doubled after a week. The patient has now booked an urgent appointment.

What you should do:
Talk to the patient, assess, and address his concerns.

Presenting complaint (P1) (ODIPARA):
D: Hello Steve I am one of the doctors in general practice here. Is your full name Steve Austin.
P: Yes.
D: Can I get your age, please, before we begin the consultation?
P: I am 75.
D: So, Steve, I can see that you have been having some concerns?
P: Yes, doctor, I was playing golf with my friend yesterday and I had a very odd sensation at that time, I don’t know what it was.
D: Tell me more about this sensation?
P: I don’t know but I felt a bit confused for a few moments and I didn’t know where I was or what I was doing. I have been having this feeling for a week now and I think it happened because of the drug I’ve been put on.
D: Can you tell me about the drug, what drug is it and why are you taking it?
P: 2 weeks ago I went to the doctor as I was going to the loo more often and it was very difficult for me to hold my urine in. I was prescribed oxybutynin 2 weeks ago, but the symptoms did not go away, so my dose was doubled a week ago.
D: Did your symptoms improve after doubling the dose?
P: Yes doctor, they did improve but then this happened and I stopped taking it yesterday.
D: Do you have any other symptoms apart from the confusion?
P: No.
D: Any fever?
P: No.
D: Any changes in your urine (cloudy, frothy, blood)?
P: No.
D: Any nausea and vomiting?
P: No.
D: Do you have any pain while passing urine?
P: No.
D: Do you have to go to the loo more frequently at night?
P: Yes.
D: How many times do you have to wake up during the night?
P: Twice, I think.
D: Any other problems with urinating, like straining or having difficulty in passing urine or dribbling at the end?
P: No, doctor.
D: Are you able to hold your urine before going to the loo?
P: Well, that was the problem that I went to the doctor in the first place about and it improved since I doubled the dose of medicine.
D: Do you feel like you are not able to completely empty your bladder?
P: No
D: Have you noticed any weight loss?
P: No doctor.
D: Any lumps and bumps anywhere?
P: No, doctor.
D: Any changes in appetite?
P: No.

Concern
D: Apart from this, is there anything else that’s concerning you?
P: Well, being confused was scary.
D: I can imagine it was.

Past medical conditions (P2)
D: Has this ever happened before?
P: No.
D: Do you have any medical conditions that I should be aware of?
P: Just this problem with the urine, nothing else.

D.E.S.A (P3) + Sexual history:
D: Are you physically active?
P: I try to be physically active, doctor.
D: Do you smoke?
P: No, doctor.
D: What about alcohol?
P: No, doctor.

M.A.F.T.O.S.A
D: Are you on any long-term medication apart from oxybutynin?
P: No.
D: What about any known allergies to any food or drugs?
P: I don’t have any known allergies.
D: Anyone in your family with similar problems or other medical conditions?
P: No, doctor.

Expectation
D: Do you have anything specific in mind that you are expecting from us?
P: I just want this to get better.

Idea
D: Do you have any idea what might be causing the problem?
P: No doctor, I have no idea.

Examination:
â—Ź Observation (Check vitals + BMI)
â—Ź Abdominal Examination
â—Ź Per rectal examination

Provisional diagnosis:
Steve, from what you told me, I understand that you had a feeling of being confused yesterday and you have been having this urge incontinence problem for which you have been taking oxybutynin with a double dose since last week. I suspect that you are correct in thinking this was caused by doubling the drug dose, as it is a known side effect of this drug.

Management:
Refer: Specialist referral to review the medication and dosage.
Involve senior.

Investigations:

  • FBC, RFT, LFT, U&E
  • Urine dipstick

Symptomatic management:

  • Lifestyle modifications including reducing caffeine, drinking an optimal amount of water, losing weight, to counter the incontinence problem to decrease the drug dosage.
  • Pelvic floor muscle training (Kegel exercises)
  • Bladder training.
  • NHS incontinence services which include special nurses and physiotherapists who can help with the issue.

Surgical management:

  • Urge Incontinence: Botulinum toxin A injection, Sacral nerve stimulation.

Specialist:
Refer to the specialist for medication review and further management of urge incontinence.

Safety-net

  • If symptoms are worsening
  • If you are not feeling yourself.
  • UTI (lethargic/ drowsy/ tired)
  • Pyelonephritis (loin pain/ fever & chills/ vomiting)
3 Likes

This Oxybutynin with diarrhoea and confusion.

Since the oxybutynin was stopped, you need to find out when and whether the confusion predates the stopping or not. Or whether it started with the diarrhoea.

In any case, kidney function test must be done as the diarrhoea could have caused hyponatremia which is a cause of confusion on it’s own

So, it’s either the oxybutynin or the diarrhoea (hyponatremia) or both.

I would want to check the functions of your kidney to check for a salt called sodium. This is because you have been having diarrhoea, which can make this salt to be low, and this can cause or contribute to the confusion.

Though oxybutynin can cause confusion but we just have to be sure if it is the only thing implicated here.