Confusion (Thiazide)

History:

  • You are an FY2 in the emergency department.
  • A 67-year-old female has presented with confusion in the morning and has been brought in by her daughter.
  • She has a history of mild fever but no symptoms of chest infection or urinary tract infection, no history of dementia, and no additional symptoms or red flags.
  • She has been diagnosed with depression and has been taking citalopram for 5 months.
  • She also has hypertension and has been taking antihypertensive medication (bendroflumethiazide).
  • Her daughter is in the cubicle and is very concerned about her mother.
  • She has consent to talk about her mother.

Task:

  • Talk to the daughter and address her concerns.

Examination and Investigations:

  • Take observations and conduct a head-to-toe examination.
  • Perform routine blood tests, liver function tests (LFT), kidney function tests (KFT), CT scan, and arterial blood gas (ABG).
  • Findings: Blood tests show hyponatremia (120 mmol). The CT scan is normal, but CRP is high.

Concerns:

  • What happened to her?
  • Is she going to be alright?

Management:

  • Greet, confirm identity, and ask about consent (don’t ask if it’s written in the stem).
  • Take a focused history including red flags, risk factors (infections, fever, dementia, medical conditions, medications), ODPARA of tiredness, past medical history, and medication history.
  • Perform ICE.
  • Verbalize examination and investigation findings.
  • Explain test results to the daughter, including hyponatremia and its relation to her mother’s presentation (low salt levels can cause confusion).
  • Explain how her medications (citalopram and thiazide) could be the cause of low salt levels leading to confusion.

Management plan:

  • She needs to be admitted, and fluids (3% NaCl infusion) will be given.
  • As she is mildly feverish and has a high CRP, we need to rule out certain infections and will treat her accordingly.
  • Involve a senior.
  • Specialist referral and medication review will be done (changing citalopram to amitriptyline).
  • Change thiazide to CCB (senior).
  • Ask psychosocial questions and determine if she needs any support.

What should we do if it’s mild hyponatremia like above 125

Check this out, I hope this answers your question:

https://plabforum.co.uk/t/hyponatremia/3054?u=userzero

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